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Brain tumor

Here you will find summaries of a selection of ongoing clinical trials on brain tumors.

Trials with medicinal products

ATRT01 (Atypical Teratoid Rhabdoid Tumors)  Clinical study of two existing treatments for atypical teratoid/rhabdoid tumors (ATRT) - open for inclusion

Dabrafenib (low grade/high grade glioma)  Clinical study of the effect of dabrafenib in combination with trametinib in children and adolescents with a low grade or high grade glioma carrying a BRAF V600 mutation - closed for inclusion

Dabrafenib Roll-over CDRB436G2401 (low grade and high grade glioma)  Clinical study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib - open for inclusion

ESMART (different tumor types) Clinical study in children with cancer into the safety and efficacy of drugs matching a specific DNA alteration in the tumor - open for inclusion

HIT-HGG-2013 (High grade glioma)  Clinical study of a new treatment for high-grade gliomas - open for inclusion

HR-MB (high-risk medulloblastoma)  An international prospective trial on clinically high-risk medulloblastoma in patients older than 3 years - open for inclusion 

INFORM2 NivEnt (various solid tumors)  Clinical study with nivolumab and entinostat in children and young adults with refractory cancer - open for inclusion

LOGGIC/FIREFLY-2 (pediatric low-grade glioma)  Clinical study of DAY101 in children, adolescent, and young adult patients with pediatric low-grade glioma (pLGG) with an abnormality in RAF (RAF alteration) - open for inclusion

LOXO-TRK-15003 (solid/CNS tumors)  Clinical study of the safety and efficacy of the drug LOXO-101 (larotrectinib) in children with advanced solid tumors or primary central nervous system tumors - closed for inclusion

PNOC022; DMG-Act (diffuse midline gliomas)  Clinical study of a new treatment of diffuse midline gliomas - open for inclusion

Ponatinib INCB084344 (leukemia/solid tumors)  Clinical study of the safety and efficacy of ponatinib for the treatment of different types of leukemia or solid tumors in children - open for inclusion

Other trials

5-ALA (supratentorial brain tumors)  Clinical study of improving the visualization of brain tumors with 5-ALA - open for inclusion

DIPG/DMG Registry (brainstem tumors)  Clinical study into the development and treatment of tumors in and around the brainstem open for inclusion

DRUG Access protocol (solid tumors)  A national protocol to facilitate access to new anti-cancer drugs and collect data from targeted anti-cancer drugs not yet eligible for reimbursement - open for inclusion

FOCUS  Clinical study to optimize dosing of fluconazole in children for the prevention or treatment of invasive fungal infections - open for inclusion

LOGGIC Core (low-grade glioma)  Clinical study into the development and course of low-grade glioma in children through extensive collection of data - open for inclusion

Nordic CMS (brain tumors)  Clinical study into the problems with speaking after surgery for a tumor in the brain or brainstem - open for inclusion

PINOCCHIO (multiple types of cancer)  Clinical study in children on the metabolism, distribution and excretion of chemotherapy in the body, also called pharmacokinetics - open for inclusion

SIMBA study (brain tumor)  Observational study to investigate the relation between cognitive performance and MRI parameters in children who have been treated for a tumor in the posterior fossa - open for inclusion

Tumor donation in Childhood Cancer patients  This study is designed to enable post-mortem tumor donation in children that die from all different types of pediatric solid and brain tumors, to enable research on end-stage disease - open for inclusion