Trials with medicinal products
ATRT01 (Atypical Teratoid Rhabdoid Tumors) Clinical study of two existing treatments for atypical teratoid/rhabdoid tumors (ATRT) - open for inclusion
Dabrafenib (low grade/high grade glioma) Clinical study of the effect of dabrafenib in combination with trametinib in children and adolescents with a low grade or high grade glioma carrying a BRAF V600 mutation - closed for inclusion
Dabrafenib Roll-over CDRB436G2401 (low grade and high grade glioma) Clinical study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib - open for inclusion
ESMART (different tumor types) Clinical study in children with cancer into the safety and efficacy of drugs matching a specific DNA alteration in the tumor - open for inclusion
HR-MB (high-risk medulloblastoma) An international prospective trial on clinically high-risk medulloblastoma in patients older than 3 years - open for inclusion
INFORM2 NivEnt (various solid tumors) Clinical study with nivolumab and entinostat in children and young adults with refractory cancer - open for inclusion
LOGGIC/FIREFLY-2 (pediatric low-grade glioma) Clinical study of DAY101 in children, adolescent, and young adult patients with pediatric low-grade glioma (pLGG) with an abnormality in RAF (RAF alteration) - open for inclusion
LOXO-TRK-15003 (solid/CNS tumors) Clinical study of the safety and efficacy of the drug LOXO-101 (larotrectinib) in children with advanced solid tumors or primary central nervous system tumors - closed for inclusion
MK-3475-051 pembrolizumab (melanoma, solid tumor, lymphoma) Clinical study with the study drug MK-3475 in children with skin cancer (melanoma), solid tumor or lymphoma - open for inclusion
PNOC022; DMG-Act (diffuse midline gliomas) Clinical study of a new treatment of diffuse midline gliomas - on hold
Ponatinib INCB084344 (leukemia/solid tumors) Clinical study of the safety and efficacy of ponatinib for the treatment of different types of leukemia or solid tumors in children - open for inclusion
Other trials
5-ALA (brain tumors) Clinical study of improving the visualization of brain tumors with 5-ALA - open for inclusion
CCISS Next study (brain tumors) Clinical study of ophthalmological abnormalities in children and adolescents after treatment for a brain tumor - open for inclusion
DAVINCY (all cancer types) Clinical study of extended use of the drug (fos)aprepitant to prevent chemotherapy-induced nausea and vomiting - open for inclusion
DIPG/DMG Registry (brainstem tumors) Clinical study into the development and treatment of tumors in and around the brainstem open for inclusion
DRUG Access protocol (solid tumors) A national protocol to facilitate access to new anti-cancer drugs and collect data from targeted anti-cancer drugs not yet eligible for reimbursement - open for inclusion
Dynamic FDG-PET Clinical study to evaluate the use of dynamic FDG-PET scan in pediatric oncology - open for inclusion
ERNIE study (brain tumors) Clinical study into an individualized neuropsychological intervention for children with a brain tumor - open for inclusion
FASTigial (brain tumors) Clinical study into the problems with speaking after a surgery of a tumor in the brain or brainstem - open for inclusion
FOCUS (all cancer types) Clinical study to optimize dosing of fluconazole in children for the prevention or treatment of invasive fungal infections - open for inclusion
HERCules study (brain tumors) Clinical study of the effects of radiotherapy on the hypothalamus and neurocognitive outcomes - open for inclusion
LOGGIC Core (low-grade glioma) Clinical study into the development and course of low-grade glioma in children through extensive collection of data - open for inclusion
MIMIC Brain (brain tumors) Clinical study of the immune system of children and young adults with brain tumors - open for inclusion
MITCH (brain tumors) Clinical study on the possibility of characterizing brain tumor metabolism in children using high-field MRI - open for inclusion
Nordic CMS (brain tumors) Clinical study into the problems with speaking after surgery for a tumor in the brain or brainstem - open for inclusion
PINOCCHIO (multiple types of cancer) Clinical study in children on the metabolism, distribution and excretion of chemotherapy in the body, also called pharmacokinetics - open for inclusion
SIMBA study (brain tumor) Observational study to investigate the relation between cognitive performance and MRI parameters in children who have been treated for a tumor in the posterior fossa - open for inclusion
Tumor donation in Childhood Cancer patients This study is designed to enable post-mortem tumor donation in children that die from all different types of pediatric solid and brain tumors, to enable research on end-stage disease - open for inclusion