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Zwaan group

Zwaan’s research program includes translational research projects in pediatric oncology, with a special focus on early drug development and acute myeloid leukemias/Down syndrome related leukemias.

PI: Prof.dr. Michel Zwaan
Phone 00 31 (0) 88 972 52 03


The research program on myeloid leukemias is done in close collaboration with the Stam group and includes identifying determinants of clinical outcome to improve risk-group stratification, and to identify novel options for targeted treatment. Down ALL projects are performed in close collaboration with the Den Boer group.

The early clinical trial program includes early phase studies of promising novel compounds requiring development in pediatric oncology, but also studies on therapeutic drug monitoring, bioequivalence studies of novel pediatric formulations and age-dependent pharmacokinetics

Each of the units has a dedicated pediatric oncologist with a focus on early clinical trials:

   Hematological malignancies

   Solid tumors

Zwaan group